￭ 학력 및 경력 

2011 박사 (University of British Columbia, UBC)

2012-2013 선임연구원 (서울대학교 수의과대학)

2013-2014 연구조교수 (서울대학교 수의과대학)

2014-2019 조교수 (가천대학교 의예과(분자의학)

2019-2024 부교수 (가천대학교 의예과(분자의학)

2024-현재 교수 (가천대학교 의예과(분자의학)

￭ 소개

줄기세포 기반 재생의료 연구실은 줄기세포 생물학과 조직공학, 그리고 organ on a chip 기술을 융합하는 다양한 연구를 진행 중.

• 분야 1: 다양한 성체줄기세포의 치료 효능을 극대화하기 위한 전략을 개발하고 있으며, 이를 위해 줄기세포의 대사 조절, 유전자 발현, 면역 조절 연구.

• 분야 2: 줄기세포의 분화 및 노화와 관련 분자생물학적 기전을 밝히는 연구.

• 분야 3: 히알루론산, 콜라겐, 젤라틴 등 다양한 천연고분자물질을 이용해 줄기세포를 3차원적으로 지지할 수 있는 바이오소재 기반 인공 조직 개발.

• 분야 4: 폐, 자궁–난소, 뇌, 고환 등 주요 장기의 미세환경을 모사하는 organ-on-a-chip 기술을 활용하여, 약물의 독성 및 효능을 예측.

￭ 키워드

줄기세포, 난치성 질환, 분화, 노화, organ-on-a-chip, 천연고분자물질

￭ 최근 연구업적(2020-현재) 

1.Kim SR, Min EK, Lee CM, Park CH, Oh CB, Jung Y, Hong, IS, A Biomarker-Driven Ovary–Endometrium Organ-on-a-Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity. Adv Sci (Weinh). 2026 Jan. [교신저자, IF=14.1].

2.Kim YH, Kim HS, Hong IS. Advances in biomaterials-based tissue engineering for regeneration of female reproductive tissues. Biofabrication. 2025 Feb 6;17(2). [교신저자, IF: 8.0].

3.Park, SR, Kook MG Kook, Kim SR, Lee CM, Lee JW, Park JK, Park CH, Oh BC, Jung YJ, Hong IS, Development of a novel testis-on-a-chip that demonstrates reciprocal crosstalk between Sertoli and Leydig cells in testicular tissue. Exp Mol Med. 2024 Jul;56(7):1591-1605. doi: 10.1038/s12276-024-01258-3. [교신저자, IF: 12.9].

4.Park SR, Min EK, Kim SR, Kim SK, Na KH, Park CH, Jung Y, Oh BC, Hong IS. Exploring Memory Function Beyond Immune Cells: ANGPTL4-Mediated Memory Functions in Tissue Resident Stem Cells. Adv Sci (Weinh). 2024 Jul;11(28):e2307545. [교신저자, IF=14.1].

5.Min EK, Kim SR, Lee CM, Na KH, Park CH, Oh BC, Jung Y, Hong IS, Identification of memory mechanism in tissue-resident stem cells via ANGPTL4 beyond immune cells upon viral antigen exposure, Mol Ther. 2024 Sep 4;32(9):3042-3058. [교신저자, IF=12.0].

6.Park SR, Kook MG, Kim SR, Lee JW, Yu YS, Park CH, Lim S, Oh BC, Jung Y, Hong IS. A microscale 3D organ on a chip for recapitulating reciprocal neuroendocrine crosstalk between the hypothalamus and the pituitary gland, Biofabrication, 2024 Feb 6;16(2). DOI: 10.1088/1758-5090/ad22f1. [교신저자, IF= 8.0].

7.Hong IS.Endometrial Stem Cells: Orchestrating Dynamic Regeneration of Endometrium and Their Implications in Diverse Endometrial Disorders, International Journal of Biological Sciences, 2024 Jan 1;20(3):864-879.[단독저자, IF= 10.0].

8.Hong IS.Endometrial stem/progenitor cells: Properties, origins, and functions. Genes Dis. 2022 Aug 31;10(3):931-947. [단독저자, IF= 9.4].

9.Park SR, Kook MG, Kim SR, Lee JW, Park CH, Oh BC, Jung Y,Hong IS. Development of cell-laden multimodular Lego-like customizable endometrial tissue assembly for successful tissue regeneration, Biomaterials Research, 2023 Apr 21;27(1):33.[교신저자, IF= 9.6].

10.Park SR, Kim SK, Kim SR, Park JR, Hong IS. A novel role of follicle stimulating hormone (FSH) in various regeneration-related functions of endometrial stem cells, Exp Mol Med. 2022 Sep;54(9)::1524-1535.[교신저자, IF: 12.9].

11.Park SR, Kim SK, Kim SR, Lee SJ, Park JR, Lim S, Hong IS. Novel roles of luteinizing hormone (LH) in tissue regeneration-associated functions in endometrial stem cells. Cell Death & Disease,  2022 Jul 13;13(7):605. [교신저자, IF=9.6].

12.Hong IS. Enhancing stem cell-based therapeutic potential by combining various bioengineering technologies. Front. Cell Dev. Biol,  2022 Jul 5;10:901661.[단독저자, IF= 4.3].

13.Park SR, Lee JW, Kim SK, Yu WJ, Lee SJ, Kim D, Kim KW, Jung JW, Hong IS. The impact of fine particulate matter (PM) on various beneficial functions of human endometrial stem cells through its key regulator SERPINB2. Exp Mol Med.  2021 Dec;53(12):1850-1865.[교신저자, IF: 12.9].

14.Park SR, Kim SR, Im JB, Park CH, Lee HY, Hong IS. 3D stem cell-laden artificial endometrium: successful endometrial regeneration and pregnancy. Biofabrication.  2021 Aug 16;13(4). DOI: 10.1088/1758-5090/ac165a. [교신저자, IF=8.0].

15.Park SR, Kim SK, Kim SR, Kim D, Kim KW, Hong IS, Lee HY, Noncanonical functions of glucocorticoids: A novel role for glucocorticoids in performing multiple beneficial functions in endometrial stem cells. Cell Death Dis. 2021 Jun 12;12(6):612. [교신저자, IF=9.6].

16.Park SR, Kim SR, Hong IS, Lee HY, A Novel Therapeutic Approach for Colorectal Cancer Stem Cells: Blocking the PI3K/Akt Signaling Axis With Caffeic Acid. Front. Front Cell Dev Biol.  2020 Dec 23;8:.585987. [교신저자, IF=4.3].

17.Park SR, Kim SR, Lee JW, Park CH, Yu WJ, Lee SJ, Chon SJ, Lee DH, Hong IS, Development of a novel dual reproductive organ on a chip: recapitulating bidirectional endocrine crosstalk between the uterine endometrium and the ovary. Biofabrication.  2020 Oct 16;13(1). DOI: 10.1088/1758-5090/abbd29. [교신저자, IF=8.0].

18.Lee HY, Hong IS, Targeting Liver Cancer Stem Cells: An Alternative Therapeutic Approach for Liver Cancer. Cancers (Basel),  2020 Sep 24;12(10):2746.[교신저자, IF=4.4].

19.Park SR, Kim SR, Im JB, Lim S, Hong IS, Tryptophanyl-tRNA Synthetase, a Novel Damage-Induced Cytokine, Significantly Increases the Therapeutic Effects of Endometrial Stem Cells, Mol Ther.  2020 Nov 4;28(11):2458-2472.[교신저자, IF=12.0].

20.Lee HY, Hong IS., Metabolic regulation and its molecular mechanisms in various stem cell functions. Curr Stem Cell Res Ther.  2020;15(6). DOI: 10.2174/1574888X15666200512105347. [교신저자, IF=2.2].

21.Park SR, Kim SR, Park CH, Lim S, Ha SY, Hong IS, Lee HY. Sonic hedgehog (SHH), a novel endogenous damage signal, activates multiple beneficial functions of human endometrial stem cells. Mol Ther. 2020 Feb 5;28(2):452-465. [교신저자, IF=12.0]