￭ 학력 및 경력 

2008 이학박사(세포생리학), 연세대학교

2008-2010 박사 후 연구원, UTSW at Dallas, TX, USA

2010-2014 박사 후 연구원, NIH, USA

2014-현재 교수 가천대학교 의과대학 

￭ 소개 

류마티스 관절염, 건선 등의 자가면역질환 및 분비관련 질환 치료와 IR injury 후 심장조직 기능회복 연구수행. 세포막 이온수송체는 세포 산-염기 균형뿐만 아니라 세포이동, 칼슘 및 염증 메커니즘과 밀접하게 관련이 있어 이온수송체학 관점에서의 병인기전 발굴 및 관련 질환 치료제 개발 연구진행중. 또한 신호전달계인 칼슘신호전달 체계를 복합적으로 규명함으로써 칼슘신호제어 약물의 생리학적 기능규명과 세포 내 신호전달 연구를 수행중임

￭ 키워드  

Molecular physiology, Cellular physiology, Autoimmune disease, Calcium signaling, Cardiochannelopathy, 류마티스 관절염, 건선, 니만픽병, 중탄산염 이온수송체 

￭ 최근 연구업적(2020-현재) 

1. Lee Eun Sun, Hyeong Jae Kim, Dongun Lee, Jung Yun Kang, Dong Min Shin, and Jeong Hee Hong. Rheumatoid arthritis severity is mediated by a crosstalk between synoviocytes and mature osteoclasts through the calcium and cytokine feedback loop. Exp Mol Med. 2025 Feb 3.;57(2):402-419. doi: 10.1038/s12276-025-01401-8.

2. Lee E, Yang D, Hong JH. Prominent Naturally Derived Oxidative-Stress-Targeting Drugs and Their Applications in Cancer Treatment. Antioxidants (Basel). 2025 Jan 3;14(1):49. doi: 10.3390/antiox14010049.

3. Kim HJ and Hong JH. Multiplicative effects of naturally derived essential oils and active components on skin tissue and skin cancers. International Journal of molecular sciences. 2024. May 15;25(10):5397. doi: 10.3390/ijms25105397.

4. Kim HJ and Hong JH. Trafficking of carbonic anhydrase 12 and bicarbonate transporters by histamine stimulation mediates intracellular acidic scenario in lung cancer cells. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2247181. doi: 10.1080/14756366.2023.2247181.

5. Lee DU, Shin DM, and Hong JH. Modulation of lysosomal Cl- mediates migration and apoptosis through the TRPML1 as a lysosomal Cl- sensor. Cells. 2023, 2023 Jul 12;12(14):1835. doi: 10.3390/cells12141835.

6. Ji M, Ryu HJ, Baek HM, Shin DM, Hong JH. Dynamic synovial fibroblasts are modulated by NBCn1 as a potential target for rheumatoid arthritis.Experimental & Molecular Medicine. 2022 Apr;54(4):503-517.

7. Kim HJ, Lee PCW, and Hong JH, Chloride Channels and Transporters: Roles beyond Classical Cellular Homeostatic pH or Ion Balance in Cancers. Cancers. 2022 Feb 9;14(4):856.

8. Ji M and Hong JH, A Cardioplegic Solution with an Understanding of a Cardiochannelopathy. Antioxidants. 2021 Nov 25; 10(12), 1878.

9. Ji M, Ryu HJ, Hong JH, Synovial Fluid of Patient With Rheumatoid Arthritis Enhanced Osmotic Sensitivity Through the Cytotoxic Edema Module in Synoviocytes. Frontiers in cell and developmental biology. 2021 Aug 31;9: 700879.