￭ 학력 및 경력 

2009-2010 박사 후 연구원, 미국 서남부텍사스 대학(UTSW)

2010-2014 Research Fellow, 미국국립보건원(NIH/NIDCR)

2014-현재 부교수, 가천대학교 의과대학

￭ 소개 

자가면역질환 및 분비관련 질환치료와 기능회복 연구수행. 세포막 수송체의 새로운 기전 및 기능을 관절변형 및 줄기세포 이동성 조절에 적용하여, 각 치료의 효과를 증대시키는 연구를 진행중. 또한 세포 내 신호전달계인 칼슘신호전달 체계를 규명함으로써 칼슘신호제어 약물의 생리학적 기능규명과 세포간 타겟 신호전달 연구 수행중 

￭ 키워드  

칼슘신호전달, 염증성 신호기전, 이온 수송체, 타액선 분비기전, 낭포성섬유종, 구강 및 안구건조증, 쇼그렌신드롬, 류마티스 관절염, 라이소좀 질환 연구 

￭ 최근 연구업적(2018-현재)  (최근 5년간의 주요연구실적)

1.     Addition of oh8dG to cardioplegia attenuated myocardial oxidative injury through the inhibition of sodium bicarbonate cotransporter activity. Antioxidants (Basel). 2022 Aug;82:105373.

2.     Physiological Overview of the Potential Link between the UPS and Ca2+ Signaling. Antioxidants (Basel). 2022 May 19;11(5):997.

3.     Dynamic synovial fibroblasts are modulated by NBCn1 as a potential target for rheumatoid arthritis. Experimental & Molecular Medicine, 2022 Apr;54(4):503-517.

4.     Chloride Channels and Transporters: Roles beyond Classical Cellular Homeostatic pH or Ion Balance in Cancers. Cancers, 2022 Feb 9;14(4):856.A Cardioplegic Solution with an Understanding of a Cardiochannelopathy. Antioxidants, 2021 Nov 25; 10(12), 1878

5.     Synovial Fluid of Patient With Rheumatoid Arthritis Enhanced Osmotic Sensitivity Through the Cytotoxic Edema Module in Synoviocytes. Frontiers in cell and developmental biology. 2021 Aug 31;9:700879.

6.     Ca²⁺ Signaling as the Untact Mode during Signaling in Metastatic Breast Cancer. Cancers. 2021 Mar 23;13(6):1473.

7.     Modulated start-up mode of cancer cell migration through spinophilin-tubular networks. Frontiers in cell and developmental biology. 2021 Mar 9;9:652791.

8.     Signaling and putative therapeutic molecules on the regulation of synoviocytes signaling in rheumatoid arthritis. Bone & Joint Research. 2021 Apr;10(4):285-297.

9.     Protective Role of IRBIT on Sodium Bicarbonate Cotransporter-n1 for Migratory Cancer Cells, Pharmaceutics. 2020 Aug 27;12(9):E816.

10.  Apoptotic lysosomal proton sponge effect in tumor tissue by cationic gold nanorods. Nanoscale 2019 Nov 14;11(42):19980-19993.