￭ 학력 및 경력

1981~1987 M.D., 부산대학교 의과대학

1995~1999 Ph.D., 부산대학교 의과대학 

1997~2000 Research Associate, Keck School of Medicine, USC

2003~2005 Visiting professor, Internal Medicine, Yale University

2005~2008 Co-Director, the Integrative Physiology Core of the Yale-NIH Mouse

Metabolic Phenotyping Center.

2007~현재 소장, 한국마우스대사성질환표현형분석센터(KMMPC)

2010~현재 소장, 국가지정대사성질환약리효능평가센터(NECMD)

2007~현재 부교수, 교수. 가천대학교 의과대학 분자의학과/내분비대사내과

￭ 소개

현대 사회에서 가장 폭발적으로 증가하는 대사증후군(비만, 당뇨병, 이상지혈증)의 발생기전을 연구하며, 비만 및 인슐린 저항성이 대사성질환의 근본적인 공통원인으로 제시하였음. 또한 비만 및 인슐린저항성을 극복할 수 있는 혁신치료타겟 발굴 및 신약개발 중개연구를 수행하고있음. 
한국마우스대사성질환표현형분석센터(KMMPC)를 기반으로 대사성질환 유전자변형마우스연구를 통한 생체 유전자기능 규명연구는 글로벌 선도 그룹으로 인정받고 있으며,

국가지정대사성질환약리효능평가센터 및 가천대길병원 연구중심 육성 R&D 사업을 통한 대사성질환 혁신 신약개발 연구도 집중적으로 수행하고 있음.

￭ 키워드

비만, 당뇨병, 이상지혈증, 지방간, 근육, 인슐린저항성, GEM표현형분석, 혁신 신약개발

￭ 최근 연구업적(2018- 현재)  (최근 5년간의 주요연구실적)

1.Bone morphogenic protein 9 is a novel thermogenic hepatokine secreted in response to cold exposure. Metabolism. 129:155139, 2022.

2. Insulin resistance: from mechanisms to therapeutic strategies. Diabetes Metab J. 46(1):15-37, 2022

3. Self-transducible LRS-UNE-L peptide enhances muscle regeneration Journal of Cachexia, Sarcopenia and Muscle. 13(2):1277-1288, 2022

4. Ablation of USP21 in skeletal muscle promotes oxidative fibre phenotype, inhibiting obesity and type 2 diabetes. J Cachexia Sarcopenia Muscle. 12(6):1669-1689, 2021.

5. TFEB-GDF15 axis protects against obesity and insulin resistance as a lysosomal stress response. Nat Metab. 3(3):410-427, 2021.

6. Microneedle array sensor for monitoring glucose in single cell using glucose oxidase-bonded polyterthiophene coated on AuZn oxide layer. Sensors and Actuators B: Chemical 320: 128416, 2020

7. Grasp55-/- mice display impaired fat absorption and resistance to high-fat diet-induced obesity. Nat Commun. 11(1):1418., 2020

8. The essential role of fructose-1,6-bisphosphatase 2 enzyme in thermal homeostasis upon cold stress. Exp Mol Med 52(3):485-496, 2020