￭ 학력 및 경력 

2004 의학박사 (약리학), 서울대학교

2012-현재 조교수, 부교수, 교수 가천대학교

2014-2020 뇌과학연구원 나노유전체센터 센터장

2021-현재 뇌과학연구원 기초연구부 부장/정서인지연구센터 센터장

￭ 소개

뉴로랩 연구실에서는 알츠하이머 치매를 포함한 퇴행성 뇌질환의 기전 및 치료법 개발을 주된 목표로 삼고 다양한 수준에서의 연구를 수행하고 있다. 또한 인지신경행동에 관한 연구도 활발하게 진행하고 있다.  

￭ 키워드

퇴행성 신경질환, 학습-기억

￭ 최근 연구업적(2022-현재)

1. Ha TY, Kim Y, Lim SM, Hong Y, Chang KA. (2025) GPR40 agonist ameliorates neurodegeneration by regulating mitochondria dysfunction and NLRP3 inflammasome in Alzheimer’s disease animal models. Biomedicine& Pharmacotherapy, 2025 Nov:192:118678

2. Yoon BH, Kim J, Sengupta S, Park CJ, Ko M, Kang JH, Ko YT, Kim Y, Lim SM, Bae Y, Choi M, Jang Y, Kwon HJ, Son HJ, Kim HJ, Sim T*, Chang KA*, Lee MS*. (2025) Targeted autophagic clearance of Tau protects against Alzheimer’s disease through amelioration of Tau-mediated lysosomal stress. Theranostics. 2025; 15(17): 9240-9260 (*Co-corresponding authors)

3. Kim KY, Shin KY, Chang KA (2025) Blood-Based Tau as a Biomarker for Early Detection and Monitoring of Alzheimer's Disease: A Systematic Review and Meta-Analysis.  Int J Mol Sci. 2025 Oct 23;26(21):10330.

4. Kim Y, Ha TY, Lee MS, Chang KA. (2025) Regulatory Mechanisms and Therapeutic Implications of Lysosomal Dysfunction in Alzheimer's Disease.Int J Biol Sci. 2025 Jan 13;21(3):1014-1031.

5. Ko G, Kim J, Hong Y, Jeon YJ, Baek HM, Lee D, Chang KA (2025) Astragalus mongholicus and Scutellaria baicalensis Extracts Mixture Target Pyroptosis in Ischemic Stroke via the NLRP3 Pathway.Int J Mol Sci. 26(2):501.

6. Hong Y, Ko G, Jeon YJ, Baek HM, Lee J, Lee D, Park J, Kim J, Chang KA (2025)Neuroprotective Efficacy of Astragalus mongholicus in Ischemic Stroke: Antioxidant and Anti-Inflammatory Mechanisms.Cells. 14(2):117

7. Ha TY, Kim JB, Kim Y, Park SM, Chang KA (2024)GPR40 agonist ameliorates neurodegeneration and motor impairment by regulating NLRP3 inflammasome in Parkinson's disease animal models.Pharmacol Res. 209:107432

8. Kim KY, Shin KY, Chang KA (2024) Potential Exosome Biomarkers for Parkinson's Disease Diagnosis: A Systematic Review and Meta-Analysis.Int J Mol Sci. 2024 May 13;25(10):5307.

9. Seo HW, Ha TY, Ko G, Jang A, Choi JW, Lee DH, Chang KA (2023)Scutellaria baicalensis Attenuated Neurological Impairment by Regulating Programmed Cell Death Pathway in Ischemic Stroke Mice, Cells, 12(17):2133.

10. Kim Y, Kim J, Kang S, Chang KA (2023) Depressive-like Behaviors Induced by mGluR5 Reduction in 6xTg in Mouse Model of Alzheimer's Disease, Int J Mol Sci. 24(16):13010.

11. Kim KY, Shin KY, Chang KA (2023)Potential Inflammatory Biomarkers for Major Depressive Disorder Related to Suicidal Behaviors: A Systematic Review.Int J Mol Sci. 2023 Sep 9;24(18):13907.

12. Ko, G.; Kim, J.; Jeon, Y.-J.; Lee, D.; Baek, H.-M.; Chang, K.-A (2023) Salvia miltiorrhiza Alleviates Memory Deficit Induced by Ischemic Brain Injury in a Transient MCAO Mouse Model by Inhibiting Ferroptosis. Antioxidants 12, 785.

13. Kim KY, Shin KY, Chang KA (2023)GFAP as a Potential Biomarker for Alzheimer's Disease: A Systematic Review and Meta-Analysis.GFAP as a Potential Biomarker for Alzheimer's Disease: A Systematic Review and Meta-Analysis.Cells. 2023 May 4;12(9):1309.

14. Yoo, C.-H.; Kim, J.; Baek, H.-M.*; Chang, K.-A*; Choe, B.-Y. (2023) Neurodegenerative Changes in the Brains of the 5xFAD Alzheimer’s Disease Model Mice Investigated by High-Field and High-Resolution Magnetic Resonance Imaging and Multi-Nuclei Magnetic Resonance Spectroscopy. Int. J. Mol. Sci. 5073. (*Co-corresponding authors)

15. Kim J, Kang S, Chang KA (2022) Effect of cx-DHED on Abnormal Glucose Transporter Expression Induced by AD Pathologies in the 5xFAD Mouse Model. Int J Mol Sci. 23(18):10602

16. Kang S, Kim J, Lee SY, Okamura N, Chang KA (2022) MicroPET Imaging Assessment of Brain Tau and Amyloid Deposition in 6×Tg Alzheimer's Disease Model Mice. Int J Mol Sci. 23(10):5485

17. Park H, Lee YB, Chang KA (2022) miR-200c suppression increases tau hyperphosphorylation by targeting 14-3-3γ in early stage of 5xFAD mouse model of Alzheimer's disease. Int J Biol Sci.18(5):2220-2234

18.  Kim J, Kang S, Choi TY, Chang KA*, Koo JW* (2022) Metabotropic glutamate receptor 5 in amygdala target neurons regulates susceptibility to chronic social stress. Biological Psychiatry, 92(2):104-115 (*Co-corresponding authors)

19.  An SSA, Shim KH, Kang S, Kim YK, Subedi L, Cho H, Hong SM, Tan MA, Jeon R*, Chang KA*, Kim SY* (2022) The potential anti-amyloidogenic candidate, SPA1413, for Alzheimer's disease.Br J Pharmacol. 179(5):1033-1048 (*Co-corresponding authors)

20.  Kim KY, Shin KY, Chang KA (2022) Potential Biomarkers for Post-Stroke Cognitive Impairment: A Systematic Review and Meta-Analysis.Int J Mol Sci. 2022 Jan 6;23(2):602.