￭ 학력 및 경력  

2002 서울대학교 미생물학과 박사

2002 서울대학교 미생물학과 박사 후 연구원

2002-2007 미국 NIH (National institute of Health) 박사 후 연구원

2018-2019 미국 NIH (National institute of Health) visiting fellow

2007-현재 가천대학교 의과대학 생화학 교실 교수

￭ 소개

본 연구진은 지금까지 암 유발 신규 유전자에 의한 1) 암줄기세포 전환 규명 2) 암줄기 전환으로 인한 암대사 조절을 통한 암미세환경 조절 메카니즘 규명 3) RNA seq. 및 metabolomics 분석을 통한 암줄기 세포 전환에 의한 새로운 암줄기세포 및 암대사 맞춤형 표식인자 탐색 및 이용 가능성 확인 4) 신규 암줄기 세포 및 암대사 조절 유전자의 유방암 발암·전이 및 암줄기 세포 전환 및 암대사에 조절 기능 규명을 통해 효과적으로 억제할 수 있는 암줄기세포 표적 치료제의 개발에 있어 중요한 작용점 확립을 통해 본 연구진의 목표인 신약 타겟 항암제 개발에 일조할 수 있을 것으로 사료된다. 

￭ 키워드

Cancer metabolism, Cancer stemness, Metastasis, EMT program

￭최근 연구업적(2018- 현재) (최근 5년간의 주요연구실적)

1. Kim, M.S., Lee, M. S., Lee, HK and Jin W. TrkC, a novel prognostic marker, induces and maintains cell survival and metastatic dissemination of Ewing sarcoma by inhibiting EWSR1-FLI1 degradation. Cell Death Disease (2022) 28;13(9):836.

2. Kim MS, Lee WS, Park Y, Jin W. TrkC-mediated inhibition of DJ-1 degradation is essential for direct regulation of pathogenesis of hepatocellular carcinoma. Cell Death Disease (2022) 13(10):850. 

3. Kim, M.S. & Jin, W. TrkB Inhibits the BMP Signaling-Mediated Growth Inhibition of Cancer Cells. Cancers (Basel) 12 (2020).

4. Jin, W. ErBb Family Proteins in Cholangiocarcinoma and Clinical Implications. J Clin Med 9 (2020).

5. Jin, W. The Role of Tyrosine Kinases as a Critical Prognostic Parameter and Its Targeted Therapies in Ewing Sarcoma. Front Cell Dev Biol 8, 613 (2020)

6. Jin, W. Novel Insights into PARK7 (DJ-1), a Potential Anti-Cancer Therapeutic Target, and Implications for Cancer Progression. J Clin Med 9 (2020).

7. Jin, W. Regulation of Src Family Kinases during Colorectal Cancer Development and Its Clinical Implications. Cancers (Basel) 12 (2020).

8. Kim, M.S. & Jin, W. TrkB-Induced Inhibition of R-SMAD/SMAD4 Activation is Essential for TGF-beta-Mediated Tumor Suppressor Activity. Cancers (Basel) 12 (2020).

9. Jin, W. Regulation of BDNF-TrkB Signaling and Potential Therapeutic Strategies for Parkinson's Disease. J Clin Med 9 (2020).

10. Jin, W. Role of JAK/STAT3 Signaling in the Regulation of Metastasis, the Transition of Cancer Stem Cells, and Chemoresistance of Cancer by Epithelial-Mesenchymal Transition. Cells 9 (2020).

11. Jin, W. Roles of TrkC Signaling in the Regulation of Tumorigenicity and Metastasis of Cancer. Cancers (Basel) 12 (2020).

12. Kim, M.S. et al. MEST induces Twist-1-mediated EMT through STAT3 activation in breast cancers. Cell Death Differ 26, 2594-2606 (2019).

13.. Lee, J.S., Kim, Y.S., Kim, E.Y. & Jin, W. Prognostic significance of CT-determined sarcopenia in patients with advanced gastric cancer. PLoS One 13, e0202700 (2018).

14. Kim, M.S. et al. Inhibitory effect of tartrate against phosphate-induced DJ-1 aggregation. Int J Biol Macromol 107, 1650-1658 (2018).

15. Han, J. et al. Decursin and decursinol angelate improve wound healing by upregulating transcription of genes encoding extracellular matrix remodeling proteins, inflammatory cytokines, and growth factors in human keratinocytes. Biochem Biophys Res Commun 499, 979-984 (2018).